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Rapid, Reversible Modulation of Blood-Brain BarrierP-Glycoprotein Transport Activity by Vascular Endothelial Growth Factor

Cellular/Molecular
Rapid, Reversible Modulation of Blood–Brain BarrierP-Glycoprotein Transport Activity by Vascular Endothelial Growth Factor

Increased brain expression of vascular endothelial growth factor (VEGF) is associated with neurological disease, brain injury, and blood–brain barrier (BBB) dysfunction. However, the specific effect of VEGF on the efflux transporter P-glycoprotein, a critical component of the BBB, is not known.

Using isolated rat brain capillaries and in situ rat brain perfusion, we determined the effect of VEGF exposure on P-glycoprotein activity in vitro and in vivo.

Reducing PTSD Severity May Improve Substance Abuse Outcomes

Do treatment improvements in PTSD severity affect substance use outcomes? A secondary analysis from a randomized clinical trial in NIDA's Clinical Trials Network.

OBJECTIVE: The purpose of the analysis was to examine the temporal course of improvement in symptoms of posttraumatic stress disorder (PTSD) and substance use disorder among women in outpatient substance abuse treatment.

Return to Duty Rate of Amputee Soldiers in the Current Conflicts in Afghanistan and Iraq.

Return to Duty Rate of Amputee Soldiers in the Current Conflicts in Afghanistan and Iraq.

Stinner DJ, Burns TC, Kirk KL, Ficke JR.

From the Department of Regenerative Medicine (D.J.S.), United Stated Army Institute of Surgical Research; and Department of Orthopaedics and Rehabilitation (T.C.B., K.L.K., J.R.F.), Brooke Army Medical Center, San Antonio, Texas.

BACKGROUND: The purpose of this study was to determine the percentage of amputee soldiers who sustained their injury during the current conflicts in Afghanistan and Iraq and have returned to duty. In addition, the authors plan to identify the factors that influence the amputee's likelihood to return to duty.

Affective Resiliency and the Cellular Mechanisms of Bipolar Disorder

Cellular mechanisms underlying affective resiliency: the role of glucocorticoid receptor- and mitochondrially-mediated plasticity.

Bipolar disorder (BPD) is a devastating psychiatric illness marked by recurrent episodes of mania and depression. While the underlying pathophysiology of BPD remains elusive, an abnormal hypothalamic-pituitary-adrenal (HPA) axis and dysfunctional glucocorticoid receptor (GR) signaling are considered hallmarks. 

The relationship between employment-related self-efficacy and quality of life following traumatic brain injury

The relationship between employment-related self-efficacy and quality of life following traumatic brain injury.

OBJECTIVES: This study examines the relative contribution of employment-related and general self-efficacy to perceptions of quality of life (QoL) for individuals with traumatic brain injury.