Psychopharmacological Treatment for Cognitive Impairment in Survivors of Traumatic Brain Injury: A Critical Review
Traumatic brain injury (TBI) is a growing national health issue that commonly results in clinically significant cognitive impairments. This article reviews and evaluates the many proposed psychopharmacological treatments for TBI-related cognitive impairment.
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Neuropharmacology and Analgesia
d-Cycloserine improves functional outcome after traumatic brain injury
with wide therapeutic window
Abstract
It has been long thought that hyperactivation of N-methyl-d-aspartate (NMDA) receptors underlies neurological decline after traumatic brain injury. However, all clinical trials with NMDA receptor antagonists failed. Since NMDA receptors are down-regulated from 4 h to 2 weeks after brain injury, activation at 24 h, rather than inhibition, of these receptors, was previously shown to be beneficial in mice.
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Review
Adult cell therapy for brain
neuronal damages and the role of tissue engineering
ABSTRACT
No long term effective treatments are currently available for
brain
neurological disorders such as stroke/cerebral ischemia, traumatic
brain injury
and neurodegenerative disorders.
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